HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 78320095, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Aminobutyric acid methyl ester hydrochloride | HCID 2756383 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 78321671 | HCID 78321671 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 78320095 | HCID 78320095 | — |
Reaction Steps
A mixture of (R)-1-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (15 mg, 0.040 mmol), methyl 4-aminobutanoate hydrochloride (6.71 mg, 0.044 mmol), HATU (16.62 mg, 0.044 mmol), and TEA (0.017 mL, 0.119 mmol) in DMF (0.4 mL) was stirred at room temperature overnight. The mixture was acidified with 1M HCl and purified by HPLC to give the title compound. LCMS m/z=477.5 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365511B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-90e4ae1579254c95944c91850ed25d5d |
| Source note | uspto-grants-2016_06 |