HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 78320396, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Tert-butyl 3-aminopropanoate hydrochloride | HCID 16218890 | — |
| Reactant | HCID 78321671 | HCID 78321671 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 78320396 | HCID 78320396 | — |
Reaction Steps
A mixture of (R)-1-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (15 mg, 0.040 mmol), tert-butyl 3-aminopropanoate hydrochloride (7.94 mg, 0.044 mmol), HATU (16.62 mg, 0.044 mmol), and TEA (0.017 mL, 0.119 mmol) in DMF (0.4 mL) was stirred at room temperature overnight. The mixture was acidified with 1M HCl and purified by HPLC. LCMS m/z=505.5 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365511B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-16faa6f91e17456b8026812ac44fd6de |
| Source note | uspto-grants-2016_06 |