Hydrochloric Acid → HCID 78320398, compound

Participants

Reaction Steps

To (R)-1-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (30.0 mg, 0.079 mmol) was added 1.25M hydrogen chloride in methanol (1.907 mL, 2.384 mmol). The reaction was stirred at room temperature for 4 h. The mixture was concentrated and purified by HPLC to give the title compound. LCMS m/z=392.5 [M+H]+; 1H NMR (400 MHz, CD3CN) δ ppm 1.27 (d, J=6.9 Hz, 0.3H), 1.46 (d, J=6.5 Hz, 2.7H), 1.67-1.84 (m, 5H), 2.01-2.12 (m, 2H), 2.23-2.33 (m, 1H), 2.59-2.67 (m, 1H), 3.05-3.21 (m, 4H), 3.36-3.47 (m, 1H), 3.51-3.58 (m, 1H), 3.61 (s, 3H), 3.73-3.84 (m, 1H), 7.40 (d, J=8.2 Hz, 2H), 7.46 (d, J=8.3 Hz, 2H), 7.62 (d, J=8.5 Hz, 2H), 7.65 (d, J=8.3 Hz, 2H).

Provenance & Evidence