HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 78321035, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Tert-butyl 4-aminobutanoate hydrochloride | HCID 24750478 | — |
| Reactant | HCID 76286162 | HCID 76286162 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 78321035 | HCID 78321035 | — |
Reaction Steps
To a solution of (R)-3-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)propanoic acid (30 mg, 0.089 mmol), tert-butyl 4-aminobutanoate hydrochloride (20.88 mg, 0.107 mmol), and TEA (0.037 mL, 0.267 mmol) in DMF (1 mL) was added HATU (40.6 mg, 0.107 mmol). The reaction was stirred at room temperature overnight. The mixture was added 1M HCl (1 mL) and purified by HPLC to give the title compound. LCMS m/z=479.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365511B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-5e51e31117c74a71b1ef1932cb83eb3f |
| Source note | uspto-grants-2016_06 |