Acetic Acid → HCID 68706406, compound

Participants

Reaction Steps

Acetic acid (12 μL, 0.21 mmol), NaCN (25 mg, 0.51 mmol) and MnO2 (152 mg, 1.7 mmol) were added to a mixture of 42a (43 mg, 0.084 mmol) in methanol (0.5 mL). The mixture was stirred for 18 h and then was filtered through Celite, washing with ethyl acetate. The filtrate was washed with water (20 mL) and the aqueous layer was further extracted with ethyl acetate (20 mL). The combined ethyl acetate solution was dried (Na2SO4), filtered and evaporated to give the title compound (45 mg, 0.083 mmol, 99%).

Provenance & Evidence