HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-N-Boc-Amino-Thiazole-5-Carboxylic Acid | HCID 22271442 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate | HCID 45117870 | — |
Reaction Steps
The third step involves adding a 2M solution of oxalyl chloride in dichloromethane to a stirred solution of 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid in tetrahydrofuran and N,N-dimethylformamide, and then stirring the solution at room temperature for 4 hours. The solvent was evaporated under reduced pressure and in vacuo to obtain tert-butyl[5-(chlorocarbonyl)-1,3-thiazol-2-yl]carbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365526B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-faf669b11568465c9b53b18b4a5afecb |
| Source note | uspto-grants-2016_06 |