HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4,6-Dichloro-2-methylpyrimidine | HCID 234997 | — |
| Reactant | 2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide | HCID 21911644 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide | HCID 11269410 | — |
Reaction Steps
The sixth step involves reacting 2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide (Formula 1c) with 4,6-dichloro-2-methylpyrimidine in the presence of sodium hydride in tetrahydrofuran to obtain N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide (Formula 1d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365526B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-edb67dbf8f3549e1b564cb2b1a067714 |
| Source note | uspto-grants-2016_06 |