3-Carboxybenzaldehyde → 3-{[4-(tert-Butoxycarbonyl)piperazin-1-yl]methyl}benzoic acid

Participants

Reaction Conditions

Reaction Steps

The solution of 3-formylbenzoic acid (300 mg, 1.83 mmol) and tert-butyl piperazine-1-carboxylate (340 mg, 1.83 mmol) in MeOH (10 mL) was stirred at 27° C. for 1 h. Then NaBH3CN (138 mg, 2.19 mmol) was added to the solution and stirred at 27° C. for 6 h. The solution was concentrated and the residue was purified by column to give the title product (320 mg, Yield 50%). LCMS (m/z): 321.2 (M+1).

Provenance & Evidence