HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202046Generated: October 31, 2026
Ammonia → 1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
https://huagongshe.com/reaction/2202046
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-[(Oxiran-2-yl)methyl]-1,2,3,4-tetrahydroisoquinoline | HCID 16784531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol | HCID 16790720 | 96% |
Reaction Steps
To a solution of 2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (17 g, 0.09 mol) in EtOH (300 mL) at −78° C. was slowly bubbled NH3 (g). The reaction mixture was then sealed and heated at 80° C. for 3 h. The reaction mixture was concentrated and the crude product was used in next step without further purification (18 g, Yield 96%). LCMS (m/z): 207.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365519B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-11ecc2c3e160463ebb19559bc676b10a |
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| Source note | uspto-grants-2016_06 |
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