HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 1-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester | HCID 3862010 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate | HCID 67131265 | — |
Reaction Steps
To a solution of 5.7 g 1-(2-chloro-benzenesulfonyl)-piperdine-3-carboxylic acid ethyl ester (17 mmol) in 30 mL THF: methanol: water (2:1:1) was added 1.08 g LiOH.H2O (25.7 mmol). The mixture was stirred at room temperature for 5-6 h and all volatiles were evaporated to dryness. The compound was used in the consecutive step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202888B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-451a63a2c58144919bdae4ecfb673cf6 |
| Source note | uspto-grants-2012_06 |