Hydrochloric Acid → HCID 66720539, compound

Participants

Reaction Steps

(1-Cyclopentyl-piperidin-4-yl)-carbamic acid tert-butyl ester (3) (6.70 g, 25 mmol, 1 equiv) was dissolved in methanol (30 mL), followed by the addition of 6 N HCl in isopropanol (10 mL). The solution was stirred at room temperature for 24 hours. Due to the incompleteness of the reaction, 6 N HCl in isopropanol (10 mL) and methanol (50 mL) were added to the solution. The solution was stirred at room temperature for another 24 hours. LC-MS indicated incompletion of the reaction. Tetrahydrofurane (20 mL), 6 N HCl in isopropanol (10 mL) and methanol (200 mL) were added to the solution. The solution was stirred at room temperature for 5 hours, followed by the addition of 6 N HCl in isopropanol (10 mL). The solution was stirred at room temperature for 72 hours. The solution was evaporated under reduced pressure to obtain 4 (4.20 g, 25 mmol, quantitative). LRMS (ES+): m/z 169.

Provenance & Evidence