Dimethylformamide dimethyl acetal → ((1E)-4,4-dimethoxy-3-oxobut-1-en-1-yl)dimethylamine

Participants

Reaction Steps

A solution of 1,1-dimethoxypropan-2-one (12 g, 101.58 mmol, 1.00 equiv) and (dimethoxymethyl)dimethylamine (12 g, 100.70 mmol, 0.99 equiv) was stirred at 100° C. for 5 h. The reaction mixture was cooled to room temperature and used in the next step directly. LCMS (method D, ESI): RT=0.94 min, m/z=174.0 [M+H]+.

Provenance & Evidence