HCID 90456052, compound → HCID 90456144, compound

Participants

Reaction Steps

A mixture of 4-(5-(hydroxymethyl)oxazol-4-yl)benzonitrile (190 mg, 0.95 mmol, 1.00 equiv) and MnO2 (1.9 g, 21.85 mmol, 23.03 equiv) in dichloromethane (5 mL) was refluxed for 2 h. The reaction mixture was cooled to room temperature and the solid material was removed by filtration. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with 0-6% of ethyl acetate in petroleum ether to yield 20 mg (11%) of 4-(5-formyloxazol-4-yl)benzonitrile as a white solid. 1H-NMR (300 MHz, CDCl3): δ 10.02 (s, 1H), 8.90 (s, 1H), 8.25 (d, J=8.4 Hz, 1H), 8.08-8.02 (m, 2H) ppm.

Provenance & Evidence