HCID 90460321, compound → HCID 90460782, compound

Participants

Reaction Steps

A mixture of 4-[5-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]benzonitrile (225 mg, 1.12 mmol, 1.00 equiv) and MnO2 (1958 mg, 22.52 mmol, 20.04 equiv) in dichloromethane (20 mL) was stirred at room temperature overnight. The solid material was removed by filtration. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with 0-50% of ethyl acetate in petroleum ether to give 110 mg (49%) of 4-(5-formyl-1H-1,2,3-triazol-1-yl)benzonitrile as a white solid. 1H NMR (400 MHz, DMSO-d6) δ: 9.96 (s, 1H), 8.70 (s, 1H), 8.15 (d, J=8.0 Hz, 2H), 7.97 (d, J=8.0 Hz, 2H) ppm.

Provenance & Evidence