HCID 90460898, compound → HCID 90460323, compound

Participants

Reaction Steps

A mixture of 4-(5-(hydroxymethyl)-1H-imidazol-1-yl)benzonitrile (80 mg, 0.40 mmol, 1.00 equiv) and MnO2 (525 mg, 6.04 mmol, 15.04 equiv) in dichloromethane (10 mL) was refluxed for 1 h. The reaction was cooled to room temperature and the solid material was removed by filtration. The filtrate was concentrated under vacuum to give 55 mg (69%) of 4-(5-formyl-1H-imidazol-1-yl)benzonitrile as a white solid. 1H-NMR (300 MHz, CDCl3): δ 9.80 (s, 1H), 8.03 (s, 1H), 7.99-7.80 (m, 3H), 7.56-7.49 (m, 2H) ppm. LCMS (method D, ESI): RT=1.06 min, m/z=198.0 [M+H]+.

Provenance & Evidence