HCID 90460960, compound → HCID 90461353, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[4-(hydroxymethyl)-1,2,5-thiadiazol-3-yl]benzonitrile (230 mg, 1.06 mmol, 1.00 equiv) and MnO2 (922 mg, 10.61 mmol, 10.02 equiv) in dichloromethane (20 mL) was stirred at 40° C. for 1.5 h. The reaction was cooled to room temperature and the solids were removed by filtration. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with 2.5-5% of ethyl acetate in petroleum ether to give 113 mg (50%) of 4-(4-formyl-1,2,5-thiadiazol-3-yl)benzonitrile as a white solid. 1H-NMR (300 MHz, CDCl3): δ 10.34 (s, 1H), 8.00 (d, J=8.4 Hz, 1H), 7.80 (d, J=8.1 Hz, 1H) ppm.

Provenance & Evidence