Dimethylformamide dimethyl acetal → 4-(Dimethylamino)-1,1-dimethoxybut-3-en-2-one

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Reaction Conditions

Reaction Steps

A mixture of 1,1-dimethoxypropan-2-one (10 g, 84.65 mmol, 1.00 equiv) and DMF-DMA (10 g, 84.03 mmol, 0.99 equiv) was stirred at 100° C. for 5 h. The resulting mixture was cooled to room temperature and concentrated under vacuum to give 18 g of crude 4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one as a brown liquid. The crude product was used in the next step without further purification.

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