HCID 90456112, compound → HCID 90461035, compound

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Reaction Steps

A mixture of 4-(5-(hydroxymethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)benzonitrile (100 mg, 0.30 mmol, 1.00 equiv) and MnO2 (260 mg, 2.99 mmol, 10.00 equiv) in dichloromethane (10 mL) was stirred at room temperature for 1 h. The solid material was removed by filtration. The filtrate was concentrated under vacuum to yield 64 mg (64%) of 4-(5-formyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)benzonitrile as a yellow solid. 1H-NMR (300 MHz, CDCl3): δ 9.94 (s, 1H), 7.93 (s, 1H), 7.76-7.56 (m, 4H), 5.75 (s, 2H), 3.66 (t, J=9.4 Hz, 2H), 0.94 (t, J=9.4 Hz, 2H), 0.04 (s, 9H) ppm. LCMS (method A, ESI): RT=1.57 min, m/z=328.0 [M+H]+.

Provenance & Evidence