Chloroform → HCID 90088357, compound

HRID 2202135Notes

Reaction equation

HRID 2202135 reaction equation
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:11]([NH:14][C:15]1[C:16](=[O:26])[O:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[CH:20][C:19]=2[OH:25])(=[O:13])[CH3:12].C(Cl)(Cl)Cl>N1C=CC=CC=1>[C:1]1([S:7]([O:25][C:19]2[CH:20]=[CH:21][CH:22]=[C:23]3[C:18]=2[O:17][C:16](=[O:26])[C:15]([NH:14][C:11](=[O:13])[CH3:12])=[CH:24]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 7369Benzenesulfonyl chlorideHCID 14418061HCID 14418061, compound

Product 1

HCID 90088357HCID 90088357, compoundYield 85.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Benzenesulfonyl chloride (4.0 g, 22.8 mmol) was added to a solution of 3-acetylamino-2-oxo-8-hydroxychromen (5.0 g, 22.8 mmol) in pyridine (50 mL) followed by stirring for one night. Chloroform (100 mL) was added thereto and crystals were filtered therefrom and washed with hexane. The crystals were dried to give 7.0 g (85%) of the title compound.

Workup

  1. filtrationcrystals were filtered
  2. washwashed with hexane
  3. customThe crystals were dried

Sources & evidence

ORD record
ord-864333afa37047898b5381368530820e
Source dataset
uspto-grants-2016_06
Patent number
US09365533B2

Reaction notes

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