HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202183Generated: October 30, 2026
Hydrochloric Acid → Benzyl 4-(2-amino-1-methoxycarbonylethyl)piperazine-1-carboxylate dihydrochloride
https://huagongshe.com/reaction/2202183
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | benzyl 4-((S)-2-tert-butoxycarbonylamino-1-methoxycarbonylethyl)piperazine-1-carboxylate | HCID 71115226 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Benzyl 4-(2-amino-1-methoxycarbonylethyl)piperazine-1-carboxylate dihydrochloride | HCID 86675018 | 90% |
Reaction Steps
A solution of 1.45 g (3.4 mmol) of benzyl 4-((S)-2-tert-butoxycarbonylamino-1-methoxycarbonylethyl)piperazine-1-carboxylate in 3.5 ml of a solution of hydrochloric acid in isopropanol, having a concentration 5-6N, and 10 ml of methanol is heated at 40° C. for 3 h and then evaporated. The residue is taken up in diethyl ether and filtered. 1.2 g (90%) of benzyl 4-(2-amino-1-methoxycarbonylethyl)piperazine-1-carboxylate dihydrochloride are obtained in the form of a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365529B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-2a49e2360c50400e8a6465e15b690acb |
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| Source note | uspto-grants-2016_06 |
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