HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202190Generated: October 30, 2026
Hydrochloric Acid → methyl (S)-3-amino-2-(4-benzylpiperazin-1-yl)propanoate trihydrochloride
https://huagongshe.com/reaction/2202190
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 71115295 | HCID 71115295 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl (S)-3-amino-2-(4-benzylpiperazin-1-yl)propanoate trihydrochloride | HCID 86675021 | 100% |
Reaction Steps
8.9 g (23.5 mmol) of methyl (S)-2-(4-benzylpiperazin-1-yl)-3-tert-butoxycarbonylaminopropanoate are placed in solution in 60 ml of methanol and in 20 ml of isopropanolic hydrochloric acid having a concentration of 5-6N. The reaction medium is stirred at 40° C. for 18 h and then concentrated under vacuum. 9.0 g (100%) of methyl (S)-3-amino-2-(4-benzylpiperazin-1-yl)propanoate trihydrochloride are obtained in the form of a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365529B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-2e93914d245d42189c6ba33b5f31b039 |
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| Source note | uspto-grants-2016_06 |
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