HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(3-tert-butyl-1-(4-cyanophenyl)-1H-pyrazol-5-yl)-3-((5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)phenyl)methyl)urea hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 1-(3-tert-Butyl-1-(4-cyanophenyl)-1H-pyrazol-5-yl)-3-((5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazole-5-yloxy)phenyl)methyl)urea | HCID 68783680 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(3-tert-butyl-1-(4-cyanophenyl)-1H-pyrazol-5-yl)-3-((5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)phenyl)methyl)urea hydrochloride | HCID 68785458 | 83% |
Reaction Steps
1-(3-tert-Butyl-1-(4-cyanophenyl)-1H-pyrazol-5-yl)-3-((5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazole-5-yloxy)phenyl)methyl)urea (0.070 g, 0.12 mmol) was added to MTBE and stirred. Saturated HCl in diethyl ether was added until a precipitate dropped out. The precipitate was collected by filtration and dried to provide 61 mg (83%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202899B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-09298fd172e94401a6a44662cfad1457 |
| Source note | uspto-grants-2012_06 |