HCID 178525084, compound → HCID 178525794, compound

HRID 2202255Notes

Reaction equation

HRID 2202255 reaction equation
[C@H:1]1([C:15]([O:17]CC2C=CC=CC=2)=[O:16])[CH2:4][C@H:3]([C:5]([O:7]CC2C=CC=CC=2)=[O:6])[CH2:2]1>CO.[C].[Pd]>[C@H:1]1([C:15]([OH:17])=[O:16])[CH2:4][C@H:3]([C:5]([OH:7])=[O:6])[CH2:2]1

Participants

4

Reactant 1

HCID 178525084HCID 178525084, compound

Product 1

HCID 178525794HCID 178525794, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A mixture of dibenzyl trans-cyclobutane-1,3-dicarboxylate (100 mg, 0.31 mmol) and 10% palladium-carbon (10 mg, 0.09 mmol, 50%, wet) in MeOH (2.0 mL) was stirred at room temperature for 5 hr under hydrogen atmosphere (1 atm). The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give crude trans-cyclobutane-1,3-dicarboxylic acid as a colorless oil.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a7928fb2cef04c8aba481c5060aefca1
Source dataset
uspto-grants-2016_06
Patent number
US09365520B2

Reaction notes

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