Hydrochloric Acid → HCID 90418937, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl-4-acetoxy-4-(3,3-difluorobutyl)piperidine-1-carboxylate (100 mg, 0.426 mmol) in MeOH (10 mL) and H2O (2 mL) was added NaOH (145 mg, 8.45 mmol). The resulting mixture was stirred at 40° C. for 4 h. After cooling to room temperature, the mixture was acidified with 2N HCl solution. After removal of MeOH, the resulting solution was extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered, and evaporated to dryness under reduced pressure to give the crude product which was used in the next step without further purification.

Provenance & Evidence