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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202352Generated: October 31, 2026

Hydrochloric Acid → HCID 90419711, compound

https://huagongshe.com/reaction/2202352

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 90418937HCID 90418937—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 90419711HCID 90419711—

Reaction Steps

The solution of tert-butyl-4-(3,3-difluorobutyl)-4-hydroxypiperidine-1-carboxylate (0.932 g, 3.2 mmol) in the solution of HCl in 1,4-dioxane (3M, 5 mL) was stirred at room temperature for 1 hour. The solution was evaporated to dryness under reduced pressure to give the product which was used in the next step without further purification. LC-MS: m/z 194.3 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09365545B2
Source datasetuspto-grants-2016_06
ORD IDord-49c3ff9ca5784f10b7b9cf54178d2c38
Source noteuspto-grants-2016_06