Sulfuric Acid → Methyl 2-chloro-4-nitrobenzoate

https://huagongshe.com/reaction/2202377

Participants

Role	Name	HCID	Charge
Reactant	Sulfuric Acid	HCID 1118	—
Reactant	2-Chloro-4-nitrobenzoic acid	HCID 7448	—
Reactant	Sodium Bicarbonate	HCID 516892	—
Solvent	Methanol	HCID 887	—
Product	Methyl 2-chloro-4-nitrobenzoate	HCID 83343	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

To a solution of 2-chloro-4-nitrobenzoic acid (10 g, 0.06 mol) in MeOH (120 mL) was added H2SO4 (5 mL). The resulting mixture was stirred at 60° C. overnight. After cooling to room temperature, the mixture was brought to pH=8 using sodium bicarbonate solution. After removal of MeOH, the resulting crude mixture was purified by column chromatography (20% CH2Cl2/PE) to afford 4 g of the title compound. LC-MS: m/z 216.6 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09365545B2
Source dataset	uspto-grants-2016_06
ORD ID	ord-03bc25c58f344d5c8e436fc5914471a6
Source note	uspto-grants-2016_06