6-Methyl-5-nitropicolinic acid → HCID 82594963, compound

HRID 2202381Notes

Reaction equation

HRID 2202381 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N+:11]([O-])=O>CO.[Pd]>[NH2:11][C:3]1[CH:4]=[CH:5][C:6]([C:8]([OH:10])=[O:9])=[N:7][C:2]=1[CH3:1]

Participants

4

Reactant 1

HCID 74720376-Methyl-5-nitropicolinic acid

Product 1

HCID 82594963HCID 82594963, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 6-methyl-5-nitropicolinic acid (31C, 500 mg, 2.75 mmol) in methanol (10 ml) was added Pd/C (50 mg). The solution was stirred at r.t. under H2 atmosphere for 1 h, when LC-MS showed that s.m. was consumed. Then the mixture was filtered and concentrated to give the crude product which was used to the next step without further purification. LC-MS: m/z 153 (M+H)+

Workup

  1. customwas consumed
  2. filtrationThen the mixture was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b8a312daf05e4cf4a7e20cd9d553d0c3
Source dataset
uspto-grants-2016_06
Patent number
US09365545B2

Reaction notes

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