HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-chloropyrazine-2-carboxylate → HCID 68436940, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-chloropyrazine-2-carboxylate | HCID 406081 | — |
| Reactant | 4-Piperidinepropanamine,1-methyl-(9CI) | HCID 23498080 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68436940 | HCID 68436940 | — |
Reaction Steps
A solution of 5-chloro-pyrazine-2-carboxylic acid methyl ester (1 equiv.) and 3-(1-methyl-piperidin-4-yl)-propylamine (1.1 equiv.) in MeOH (0.25 M) heated at 100° C. in a sealed tube for 4 h. The mixture was cooled to rt and concentrated to give a crude product which was purified by FCC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365548B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-9b3e57a890824ecaaee84c5789c7488c |
| Source note | uspto-grants-2016_06 |