HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-phenyl-1H-pyrazol-5-yl)boronic acid → 1-(4-Fluoro-phenyl)-6-(2-phenyl-2H-pyrazol-3-yl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-phenyl-1H-pyrazol-5-yl)boronic acid | HCID 59436217 | — |
| Reactant | 6-bromo-1-(4-fluoro-phenyl)-1H-benzo[d]imidazole | HCID 90095139 | — |
| Product | 1-(4-Fluoro-phenyl)-6-(2-phenyl-2H-pyrazol-3-yl)-1H-benzoimidazole | HCID 73673432 | — |
Reaction Steps
The title compound, light brown solid (26 mg, 21%), MS (ISP) m/z=355.2 [(M+H)+], mp 194° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(4-fluoro-phenyl)-1H-benzo[d]imidazole (intermediate G) (100 mg, 344 μmol) and commercially available 1-phenyl-1H-pyrazol-5-ylboronic acid [CAS No. 1238702-56-1] (83.9 mg, 447 μmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365550B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-dbe6eb45abea43bc85859c6b2aaabe1a |
| Source note | uspto-grants-2016_06 |