6-bromo-1-(4-fluoro-phenyl)-1H-benzo[d]imidazole → 1-(4-Fluoro-phenyl)-6-[2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-benzoimidazole

Participants

Reaction Steps

The title compound, yellow solid (45 mg, 31%), MS (ISP) m/z=423.5 [(M+H)+], mp 167° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(4-fluoro-phenyl)-1H-benzo[d]imidazole (intermediate G) (100 mg, 344 μmol) and 1-(4-trifluoromethyl-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate C) (96.7 mg, 378 μmol).

Provenance & Evidence