HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-chloro-phenyl)-1H-pyrazol-5-ylboronic acid → 6-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-1-(2,4-difluoro-phenyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-chloro-phenyl)-1H-pyrazol-5-ylboronic acid | HCID 90095126 | — |
| Reactant | 6-bromo-1-(2,4-difluoro-phenyl)-1H-benzo[d]imidazole | HCID 90095419 | — |
| Product | 6-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-1-(2,4-difluoro-phenyl)-1H-benzoimidazole | HCID 73673671 | — |
Reaction Steps
The title compound, off-white solid (29 mg, 22%), MS (ISP) m/z=407.4 [(M+H)+], mp 133° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(2,4-difluoro-phenyl)-1H-benzo[d]imidazole (intermediate K) (100 mg, 324 μmol) and 1-(4-chloro-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate D) (79.2 mg, 356 μmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365550B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-8bc3fe62b32d4b25a87f53af5eeb8aea |
| Source note | uspto-grants-2016_06 |