1-(4-Fluorophenyl)-1H-pyrazol-5-ylboronic acid → 1-(2,4-Difluoro-phenyl)-6-[2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-benzoimidazole

Participants

Reaction Steps

The title compound, light brown solid (69 mg, 55%), MS (ISP) m/z=391.5 [(M+H)+], mp 152° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(2,4-difluoro-phenyl)-1H-benzo[d]imidazole (intermediate K) (100 mg, 324 μmol) and 1-(4-fluoro-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate A) (79.9 mg, 388 μmol).

Provenance & Evidence