2,3-Diaminobenzoic acid methyl ester → 2-(3-Methylamino-propyl)-1H-benzoimidazole-4-carboxylic acid methyl ester

HRID 220247Notes

Reaction equation

HRID 220247 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH2:10])[C:5]=1[NH2:11].CO[C:15]1C(OC)=C[C:18]2[NH:19][C:20](CCCNC)=N[C:17]=2[CH:16]=1>>[CH3:1][O:2][C:3]([C:4]1[C:5]2[N:11]=[C:15]([CH2:16][CH2:17][CH2:18][NH:19][CH3:20])[NH:10][C:6]=2[CH:7]=[CH:8][CH:9]=1)=[O:12]

Participants

3

Reactant 2

HCID 5718252,3-Diaminobenzoic acid methyl esterHCID 61363740[3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine

Product 1

HCID 684138902-(3-Methylamino-propyl)-1H-benzoimidazole-4-carboxylic acid methyl ester

Procedure

Prepared from 2,3-diamino-benzoic acid methyl ester (J. Med. Chem. 2000, 43(22), 4084-4097) in analogy to the methods described for [3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amine.

Sources & evidence

ORD record
ord-e8fc2548068c40988efa128c8da091c5
Source dataset
uspto-grants-2012_06
Patent number
US08202885B2

Reaction notes

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