HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-bromo-1-pyridin-4-yl-1H-benzoimidazole → 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-pyridin-4-yl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-bromo-1-pyridin-4-yl-1H-benzoimidazole | HCID 83450706 | — |
| Reactant | 1-(4-Fluorophenyl)-1H-pyrazol-5-ylboronic acid | HCID 90095170 | — |
| Product | 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-pyridin-4-yl-1H-benzoimidazole | HCID 73671875 | — |
Reaction Steps
The title compound, off-white solid (62 mg, 48%), MS (ISP) m/z=356.4 [(M+H)+], mp 199° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-pyridin-4-yl-1H-benzoimidazole (intermediate L) (100 mg, 365 μmol) and 1-(4-fluoro-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate A) (90.2 mg, 438 μmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365550B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-526128c2ab42443a9c4b706202dea632 |
| Source note | uspto-grants-2016_06 |