6-bromo-1-(4-chloro-2-fluoro-phenyl)-1H-benzo[d]imidazole → 1-(4-Chloro-2-fluoro-phenyl)-6-[2-(4-chloro-phenyl)-2H-pyrazol-3-yl]-1H-benzoimidazole

Participants

Reaction Steps

The title compound, white solid (23 mg, 18%), MS (ISP) m/z=423.4 [(M+H)+], mp 158° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(4-chloro-2-fluoro-phenyl)-1H-benzo[d]imidazole (intermediate M) (100 mg, 307 μmol) and 1-(4-chloro-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate D) (82.1 mg, 369 μmol).

Provenance & Evidence