HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-bromo-1-(4-methoxy-phenyl)-1H-benzo[d]imidazole → 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-methoxy-phenyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-bromo-1-(4-methoxy-phenyl)-1H-benzo[d]imidazole | HCID 71295672 | — |
| Reactant | 1-(4-Fluorophenyl)-1H-pyrazol-5-ylboronic acid | HCID 90095170 | — |
| Product | 6-[2-(4-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-methoxy-phenyl)-1H-benzoimidazole | HCID 73671879 | — |
Reaction Steps
The title compound, off-white solid (34 mg, 27%), MS (ISP) m/z=385.5 [(M+H)+], mp 143° C., was prepared in accordance with the general method of example 1 from 6-bromo-1-(4-methoxy-phenyl)-1H-benzo[d]imidazole (intermediate N) (100 mg, 330 μmol) and 1-(4-fluoro-phenyl)-1H-pyrazol-5-ylboronic acid (intermediate A) (81.6 mg, 396 μmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365550B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-24abb758afd04054a57e43bf10c8e3c2 |
| Source note | uspto-grants-2016_06 |