2-Methylpyridine-5-boronic acid → HCID 58442348, compound

HRID 2202491Notes

Reaction equation

HRID 2202491 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:4][NH:5][C:6]([C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]([F:18])([F:17])[F:16])=[C:10](Br)[N:9]=1)=[O:7].[CH3:27][C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][N:29]=1>>[F:1][C:2]([F:26])([F:25])[C:3]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10]([C:31]2[CH:30]=[N:29][C:28]([CH3:27])=[CH:33][CH:32]=2)[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:12][C:13]=1[NH2:14])=[O:7]

Participants

3

Reactant 2

HCID 27630812-Methylpyridine-5-boronic acidHCID 53472279HCID 53472279, compound

Product 1

HCID 58442348HCID 58442348, compound

Procedure

This compound was prepared from 3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-2-trifluoromethyl-propyl)-amide (Ex. 1.28) and 2-methylpyridine-5-boronic acid analogously to Example 8. LC-MS Rt 1.28 min; 477[M+H]+; (Method 2minLC_v002); 1H NMR (400 MHz, MeOD) δ 8.50 (1H, s), 7.85 (1H, dd), 7.69 (1H, s), 7.40 (1H, d), 4.00 (2H, s), 2.62 (3H, s).

Sources & evidence

ORD record
ord-dbc61b75b05840208f955b40e13b60d9
Source dataset
uspto-grants-2016_06
Patent number
US09365552B2

Reaction notes

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