HCID 178419731, compound → 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine

3-Nitro-5-(trifluoromethyl)pyridin-2-ol (31.00 g, 149 mmol) was dissolved in acetonitrile (250 ml) to give a dark brown solution. Phosphorus(V) oxybromide (85 g, 298 mmol) was added and the mixture was heated at reflux for 4.5 hours and then stirred at RT overnight. The reaction mixture was quenched by pouring into vigorously stirring water (600 ml) containing sodium hydrogencarbonate (110 g). The dark brown mixture was extracted with DCM (3×200 ml) and the organic phase was washed with water (200 ml) and brine (100 ml), dried (MgSO4) and concentrated in vacuo to afford the title product as a brown oil. 1H-NMR: [400 MHz, CDCl3, δH 8.87 (1H, d, J=1.4 Hz, ArH), 8.39 (1H, d, J=1.9 Hz, ArH).

1. customto give a dark brown solution
2. temperaturethe mixture was heated
3. temperatureat reflux for 4.5 hours
4. customThe reaction mixture was quenched
5. additionby pouring into vigorously stirring water (600 ml)
6. additioncontaining sodium hydrogencarbonate (110 g)
7. extractionThe dark brown mixture was extracted with DCM (3×200 ml)
8. washthe organic phase was washed with water (200 ml) and brine (100 ml)
9. dry with materialdried (MgSO4)
10. concentrationconcentrated in vacuo

ORD record

ord-8d4f43b5a0914c228ab27eeaaa609966

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09365552B2