HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chloro-2-methylphenyl)boronic acid → 3-Amino-6-(4-chloro-2-methyl-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chloro-2-methylphenyl)boronic acid | HCID 5017600 | — |
| Reactant | Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate | HCID 58964428 | — |
| Product | 3-Amino-6-(4-chloro-2-methyl-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester | HCID 58442353 | — |
Reaction Steps
This compound was prepared from 3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) and 4-chloro-2-methylphenylboronic acid analogously to Intermediate H; LC-MS Rt=1.53 mins, [M+H]+ 331 (Method 2minLC_v002).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365552B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-b832225a44624fe8b1e5ef20684d9185 |
| Source note | uspto-grants-2016_06 |