HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-amino-6-(oxazol-2-yl)-5-(trifluoromethyl)picolinate → 3-Amino-6-furan-2-yl-5-trifluoromethyl-pyrazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-amino-6-(oxazol-2-yl)-5-(trifluoromethyl)picolinate | HCID 67383553 | — |
| Reactant | Ethyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate | HCID 72942096 | — |
| Reactant | Tributyltin 2-furylstannane | HCID 131729901 | — |
| Product | 3-Amino-6-furan-2-yl-5-trifluoromethyl-pyrazine-2-carboxylic acid | HCID 58442354 | — |
Reaction Steps
The title compound was prepared from 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate C1) and tributyltin-2-furylstannane analogously to methyl 3-amino-6-(oxazol-2-yl)-5-(trifluoromethyl)picolinate (Intermediate P)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365552B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-68c2b8be31334cacae92cce63abffbf1 |
| Source note | uspto-grants-2016_06 |