Hydrazine → 3,3,3-Trifluoro-2-methoxy-2-methylpropan-1-amine

HRID 2202542Notes

Reaction equation

HRID 2202542 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([O:17][CH3:18])([CH3:16])[CH2:4][N:5]1C(=O)C2C(=CC=CC=2)C1=O.NN>>[F:1][C:2]([F:20])([F:19])[C:3]([O:17][CH3:18])([CH3:16])[CH2:4][NH2:5]

Participants

3

Reactant 2

HCID 9321HydrazineHCID 67383555HCID 67383555, compound

Product 1

HCID 584423513,3,3-Trifluoro-2-methoxy-2-methylpropan-1-amine

Procedure

A mixture comprising 2-(3,3,3-trifluoro-2-methoxy-2-methylpropyl)isoindoline-1,3-dione (272 mg, 0.95 mmol) and hydrazine (0.033 ml, 1.045 mmol) was stirred at 75° C. for 4 hours. After cooling to RT, the mixture was filtered and the filtrate was concentrated in vacuo to afford the title product which was used without further purification (no characterisation data available).

Workup

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-63650cf33a4d4dea84d4278a0c43a4b1
Source dataset
uspto-grants-2016_06
Patent number
US09365552B2

Reaction notes

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