HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202552Generated: November 1, 2026
Potassium Carbonate → HCID 90120215, compound
https://huagongshe.com/reaction/2202552
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Methoxy-2-naphthaleneboronic acid | HCID 4641692 | — |
| Reactant | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| Reactant | HCID 90120330 | HCID 90120330 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 90120215 | HCID 90120215 | — |
Reaction Steps
A degassed microwave vial was charged with D4, (6-methoxy-2-naphthyl)boronic acid (2 eq.), PdCl2(dppf)2 (0.2 eq.) and K2CO3 (3 eq.). A degassed solution of DME/H2O (1:1, 0.05 M) was added and the suspension was degassed for further 10 minutes and then heated at 110° C. for 30 min. After cooling, reaction mixture was diluted with EtOAc and filtered through a pad of Solka-Floc®. The filtrate was washed with sat. aq. NaHCO3 sol., brine, dried over Na2SO4, filtered and concentrated to give a dark red residue. The resulting crude was purified by column chromatography (eluent: petroleum ether/EtOAc from 95:5 to 1:1) to give the title compound as a pale yellow solid. MS (ES+) C33H39N3O5: 558 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365541B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-6ad31ac997184afcb9ce9044f735faf4 |
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| Source note | uspto-grants-2016_06 |
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