HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-1-(2-methoxyquinolin-3-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl(2-(2-methoxyquinolin-3-yl)-2-oxoethyl)carbamate | HCID 90149566 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | 2-Amino-1-(2-methoxyquinolin-3-yl)ethan-1-one | HCID 90036655 | — |
Reaction Steps
F1 was solubilized in dioxane (30 mL) and treated with 16 mL of 4N HCl in dioxane at 0° C. Mixture was stirred for 1 h at room temperature, poured in sat. aq. NaHCO3 and extracted with dichloromethane. The organic phase was dried over Na2SO4, filtered and concentrated to give the title compound which was used as such in the next step. MS (ES+) C12H12N2O2: 217 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365541B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-49682dbf04c044c5bae1f276817298d4 |
| Source note | uspto-grants-2016_06 |