HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202560Generated: November 2, 2026
Toluene → (S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid
https://huagongshe.com/reaction/2202560
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate | HCID 90119905 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid | HCID 90149568 | — |
Reaction Steps
To a stirred solution of F4 in DCM (0.11 M) cooled to 0° C. TFA (15 eq.) was slowly added. The reaction mixture was stirred at 0° C. for 3 days. The solvent was evaporated to afford an oily residue that was co-evaporated first with toluene then with Et2O to give the title compound as a pale yellow solid which was used directly in the next step. MS (ES+) C28H29N3O6: 504 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365541B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-300d30553e53404d8a825958c29c31d7 |
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| Source note | uspto-grants-2016_06 |
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