反应详情

To a solution of (i) (151 mg, 0.97 mmol) in EtOH (54 mL) was added 10% Pd/C (50 mg, 0.05 mmol). The reaction was degassed and purged with hydrogen at balloon pressure (×3) then stirred under hydrogen at RT for 16 h. The reaction mixture was filtered and the residue washed with acetonitrile (10 mL). The combined organics were concentrated in vacuo and the residue, (ii) (148 mg), was used without further purification.

1. customThe reaction was degassed
2. custompurged with hydrogen at balloon pressure (×3)
3. filtrationThe reaction mixture was filtered
4. washthe residue washed with acetonitrile (10 mL)
5. concentrationThe combined organics were concentrated in vacuo
6. customthe residue, (ii) (148 mg), was used without further purification