Acetonitrile → HCID 86680282, compound

Participants

Reaction Steps

A mixture of 401 mg of 4-benzhydryloxypiperidine synthesized in Production Example 1, 288 mg of methyl 5-chloromethylfuran-2-carboxylate, 352 mg of potassium carbonate, and 3.5 mL of acetonitrile was stirred for 18 hours. The reaction solution was diluted with ethyl acetate and then thrown into water, and the organic layer was collected by separation. The organic layer was washed with a saturated saline solution and then dried over magnesium sulfate. The solvent was distilled off. The resulting product was subjected to a silica gel column chromatography (chloroform/acetone (volume ratio)=20:1 to 10:1) to give the title compound (475 mg).

Provenance & Evidence