Hydrochloric Acid → HCID 54673294, compound

Participants

Reaction Steps

A mixture of 465 mg of methyl 5-(4-benzhydryloxypiperidin-1-ylmethyl)furan-2-carboxylate synthesized in Production Example 2, 1.7 mL of ethanol, and 3.4 mL of a 1-N sodium hydroxide aqueous solution was heated under reflux for 40 minutes. To the mixture were added 10 mL of water and 3.4 mL of 1-N hydrochloric acid, and the resulting mixture was stirred. The precipitated crystal was separated by filtration and washed with water. The resulting product was dried to give the title compound (316 mg).

Provenance & Evidence