1-Propanol → HCID 86680283, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 721 mg of 5-(4-benzhydryloxypiperidin-1-ylmethyl)-2-chloropyridine synthesized in Production Example 36, 21 mg of palladium acetate, 41 mg of 1,3-bis(diphenylphosphino)propane, 380 mg of potassium carbonate, 7.0 mL of n-propanol, and 3.5 mL of N,N-dimethylformamide was stirred under a carbon monoxide atmosphere at an external temperature of 90° C. for 7 hours. After the solvent was distilled off, the mixture was diluted with ethyl acetate. The resulting mixture was thrown into water, and the organic layer was collected by separation. The organic layer was washed with a saturated saline solution and then dried over magnesium sulfate. After the solvent was distilled off, the resulting product was subjected to a p-TLC to give the title compound (569 mg).

Provenance & Evidence