Sodium Hydroxide → HCID 70647869, compound

HRID 2202580Notes

Reaction equation

HRID 2202580 reaction equation
[CH:1]([O:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]2[N:28]=[C:27]([C:29]([O:31]C)=[O:30])[CH:26]=[CH:25][CH:24]=2)=[O:22])[CH2:17][CH2:16]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH:1]([O:14][CH:15]1[CH2:16][CH2:17][N:18]([C:21]([C:23]2[N:28]=[C:27]([C:29]([OH:31])=[O:30])[CH:26]=[CH:25][CH:24]=2)=[O:22])[CH2:19][CH2:20]1)([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70648090HCID 70648090, compound

Product 1

HCID 70647869HCID 70647869, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into a 50-mL recovery flask (eggplant flask), 250 mg (0.58 mmol) of methyl 6-(4-benzhydryloxypiperidine-1-carbonyl)pyridine-2-carboxylate synthesized in Production Example 42 was fed, and the compound was dissolved in 10 mL of ethanol. To the flask, 0.9 mL of 1-N sodium hydroxide was added, and the reaction was conducted at a room temperature. After the completion of the reaction was confirmed, the contents in the system were concentrated, and the residue was diluted with water. The diluted residue was neutralized with 1-N hydrochloric acid, and the resulting white crystal was filtered by suction, and the separated product was dried under a reduced pressure to give the title compound (200 mg (83%).

Workup

  1. customwas conducted at a room temperature
  2. concentrationthe contents in the system were concentrated
  3. additionthe residue was diluted with water
  4. filtrationthe resulting white crystal was filtered by suction
  5. customthe separated product was dried under a reduced pressure

Sources & evidence

ORD record
ord-31765c64352441948a6e39f85a05d091
Source dataset
uspto-grants-2016_06
Patent number
US09365553B2

Reaction notes

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