4-Benzhydryloxypiperidine → HCID 86680286, compound

Participants

Reaction Conditions

Reaction Steps

Into a 100-mL three-neck flask, 1.1 g (4.0 mmol) of 4-benzhydryloxypiperidine synthesized in Production Example 1, 1.0 g (4.0 mmol) of methyl N-tert-butoxycarbonyl-5-formylpyrrole-2-carboxylate, and 20 mL of dichloromethane were fed under an argon atmosphere, and the internal temperature was cooled to 0° C. Thereinto, 1.3 g (6.1 mmol, 1.5 eq.) of sodium triacetoxyborohydride was added at an internal temperature of not higher than −5° C., and the mixture was stirred for 5 minutes at the same temperature. Then, the mixture was heated to a room temperature and stirred overnight.

Provenance & Evidence